This enzyme class serves the human body in diverse ways. Some serine proteases, such as, the digestive enzymes trypsin and chymotrypsin, cleave a broad spectrum ...

Apr 21, 2022 · The trypsin-like proteases (TLPs) catalyse the hydrolysis of peptides and proteins at arginine and lysine residues and are one of the most ...

The serine hydrolase enzyme family is one of the largest and most diverse enzyme classes including proteases, peptidases, lipases, esterases, and amidases, ...

Nov 17, 2010 · These data demonstrate that WWL222 acts as a selective and efficacious inhibitor of ABHD11 in vivo. To confirm that other carbamate hits also ...

(A) General strategy for developing selective ABPs for serine hydrolase targets by derivatizing small-molecule probe scaffolds with diverse libraries of readily.

Feb 16, 2022 · Here we report a strategy for creating mechanism-based, light-activated protease and hydrolase substrate traps in complex mixtures and live ...

Aug 22, 2012 · Activity-based protein profiling (ABPP) is a newly emerging technique that uses active site-directed probes to monitor the functional status ...

Many serine proteases are therapeutic targets because they play key roles in disease. Katz et al. discovered that zinc(II) complexes of the bis(5-amidino-2- ...

Considering that many serine proteases exist in vivo as inactive complexes with endogenous inhibitory proteins (7, 8, 26), we compared the ability of FP ...

Nov 26, 2019 · This approach provided a detailed census of active serine hydrolases in the asexual parasite, with identification of 21 active serine hydrolases ...